Metabolism of 17α-Ethynyl-Estrenol in Rabbit
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چکیده
منابع مشابه
17α-Ethynyl-5α-androstane-3α, 17β-diol Treatment of MNU-Induced Mammary Cancer in Rats
N-methyl-N-nitrosourea (MNU) induces estrogen-dependent mammary tumors in female Lewis rats. We explored the antineoplastic activity of a synthetic androstane derivative, 17α-ethynyl-5α-androstane-3α, 17β-diol (HE3235), as a single agent or in combination with docetaxel compared to tamoxifen, anastrazole, and docetaxel monotherapies against MNU-induced mammary tumors in female Lewis rats. Treat...
متن کاملConversion of 1 7 a - Ethyny 1 - 4 - Estrene - 1 7 fi - ol to 1 7 a - Ethynyl - 1 9 - Nortestosterone in Rabbit Liver
Demonstration of remarkable biological effect of 3-deoxy-steroid confused the view about the mechanism of action of steroid,2) 3) while it has long been believed that the oxygen function at C-3 of steroid molecule is closely related to the mechanism of steroid action.1) 17a-Ethyny1-4-estrene-178-ol (ethynyl-estrenol) is one such compound which has no oxygen function at C-3 and shows remerkable ...
متن کامل17α-Ethynyl-3-methoxyestra-1,3,5(10),9(11)-tetraen-17-ol
In the title compound, C(21)H(24)O(2), rings B, C and D adopt half-chair, distorted half-chair and envelope conformations, respectively. In the crystal structure, there is an inter-molecular O-H⋯O hydrogen bond. The mol-ecules are arranged in a head-to-tail fashion, with the meth-oxy and hydr-oxy groups forming a two-dimensional hydrogen-bond network.
متن کاملStudies of the pharmacology of 17α-ethynyl-androst-5-ene-3β,7β,17β-triol, a synthetic anti-inflammatory androstene.
17α-Ethynyl-androst-5ene-3β, 7β, 17β-triol (HE3286) is an orally bioavailable analogue of androst-5-ene-3β,7β,17β-triol, a non-glucocorticoid anti-inflammatory metabolite of the adrenal steroid, dehydroepiandrosterone. The pharmacology of HE3286 was characterized in preparation for clinical trials in type 2 diabetes mellitus and other diseases of inflammation. Interactions with nuclear hormone ...
متن کاملMolecular Targets for 17α-Ethynyl-5-Androstene-3β,7β,17β-Triol, an Anti-Inflammatory Agent Derived from the Human Metabolome
HE3286, 17α-ethynyl-5-androstene-3β, 7β, 17β-triol, is a novel synthetic compound related to the endogenous sterol 5-androstene-3β, 7β, 17β-triol (β-AET), a metabolite of the abundant adrenal steroid dehydroepiandrosterone (DHEA). HE3286 has shown efficacy in clinical studies in impaired glucose tolerance and type 2 diabetes, and in vivo models of types 1 and 2 diabetes, autoimmunity, and infla...
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ژورنال
عنوان ژورنال: Folia Endocrinologica Japonica
سال: 1969
ISSN: 0029-0661
DOI: 10.1507/endocrine1927.44.12_1309